[Diabetology at the threshold of the 21st century].

  title={[Diabetology at the threshold of the 21st century].},
  author={Miss Marijke Van Andel},
  journal={Vnitrni lekarstvi},
  volume={47 5},
Scientific advances in the 19th and 20th centuries led to the discovery of insulin, the fundamental therapeutic means for treatment of diabetes mellitus type 1 at the onset of the twenties, to the introduction of sulfonylurea derivatives and biguanides in the fifties and sixties. The discovery of the principle of radioimmunoassay at the end of the fifties made it possible to investigate insulin secretion and to achieve a more accurate understanding of the pathogenesis of type 1 and 2 diabetes… CONTINUE READING