[Development of highly nuclease-resistant chemically-modified oligonucleotides].

  title={[Development of highly nuclease-resistant chemically-modified oligonucleotides].},
  author={Akira Matsuda},
  journal={Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan},
  volume={131 2},
  • Akira Matsuda
  • Published 2011 in
    Yakugaku zasshi : Journal of the Pharmaceutical…
Chemical modification of therapeutic oligodeoxyribonucleotides (ODNs) is necessary to avoid not only degradation by endo- and exo-nucleases but also recognition by sensors such as an innate immune system. We have been developing modified nucleosides having an aminoalky linker at the pyrimidine nucleobase or sugar moiety. ODNs containing 5-N-(6-aminohexyl)carbamoyl-2'-deoxyuridine (7) were thermally stabilized about 3°C per modification and were about 160 times more stable to hydrolysis by snake… CONTINUE READING