[Development of fluoropyrimidine derivatives].

  title={[Development of fluoropyrimidine derivatives].},
  author={Setsuro Fujii and Tetsuhiko Shirasaka},
  journal={Gan to kagaku ryoho. Cancer & chemotherapy},
  volume={11 11},
5-Fluorouracil (5-FU), first synthesized by Heidelberger et al. in 1957 has been used extensively in the treatment of cancer. In the process of development antitumor drugs in fluoropyrimidine, 5-FU and 5-fluorodeoxyuridine (FdUrd) were chosen because these two drugs relatively were incorporated into tumor tissues more than into normal tissues. The toxicity of 5-FU seems to be proportional to its concentration in blood. To be effective clinically, the concentration of a therapeutic drugs (5-FU… CONTINUE READING