Corpus ID: 37561631

[Development of fluorinated pyrimidines in Japan].

  title={[Development of fluorinated pyrimidines in Japan].},
  author={T. Taguchi},
  journal={Gan to kagaku ryoho. Cancer & chemotherapy},
  volume={20 1},
  • T. Taguchi
  • Published 1993
  • Medicine
  • Gan to kagaku ryoho. Cancer & chemotherapy
  • Four fluorinated pyrimidines that are in the stage of clinical trials at present in Japan were reviewed: BOF-A2, Ro09-1390, TT-62 and S-1. Both BOF-A 2 and S-1 are a compound of 5-FU derivative combined or mixed with an inhibitor of 5-FU degradation in order to prolong the blood 5-FU level as well as increase selective toxicity to tumor. Furthermore, an inhibitor of 5-FU phosphorylation in G1 tract contained in S-1 reduces G1 toxicity such as diarrhea etc due to prolongation of blood 5-FU level… CONTINUE READING