[Development of fluorinated pyrimidines in Japan].
@article{Taguchi1993DevelopmentOF,
title={[Development of fluorinated pyrimidines in Japan].},
author={T. Taguchi},
journal={Gan to kagaku ryoho. Cancer & chemotherapy},
year={1993},
volume={20 1},
pages={
10-8
}
}Four fluorinated pyrimidines that are in the stage of clinical trials at present in Japan were reviewed: BOF-A2, Ro09-1390, TT-62 and S-1. Both BOF-A 2 and S-1 are a compound of 5-FU derivative combined or mixed with an inhibitor of 5-FU degradation in order to prolong the blood 5-FU level as well as increase selective toxicity to tumor. Furthermore, an inhibitor of 5-FU phosphorylation in G1 tract contained in S-1 reduces G1 toxicity such as diarrhea etc due to prolongation of blood 5-FU level… CONTINUE READING