[Development and validation of a new HPLC method for determination of Lamotrigine and clinical application].


BACKGROUND Lamotrigine is an effective anticonvulsant drug used in the treatment of epilepsy. It has a narrow therapeutic range, a large inter and intra-individual pharmacokinetic variability and some concentration-dependent side effects. AIM The aim of this study was to develop and validate a new method for lamotrigine quantitation in plasma using HPLC… (More)


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