[Determination of azathiopurine and 6-mercaptopurine in serum by reversed-phase high performance liquid chromatography].

Abstract

A method for simultaneous determination of azathiopurine(AZP) and its metabolite 6-mercaptopurine (6-MP) concentration in serum has been developed. Reversed-phase high performance liquid chromatography with gradient elution and dual wavelength detection was employed. After protein precipitation with acetonitrile, the serum sample was evaporated to dryness… (More)

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