[Detection of mutants of the "a" determinant region of hepatitis B surface antigen S gene among Wuhan childhood patients].

@article{Hu2005DetectionOM,
  title={[Detection of mutants of the "a" determinant region of hepatitis B surface antigen S gene among Wuhan childhood patients].},
  author={Quan Hu and Jian-guo Huang and Yan-chang Lei and Hong-ping Huang and Yan Yang and Dong-liang Yang},
  journal={Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology},
  year={2005},
  volume={13 8},
  pages={594-6}
}
OBJECTIVE To investigate whether the presence of HBV mutant in vaccinees simply reflects the prevalence of HBV mutant in a specific geographic area or is indeed due to the immune pressure induced by vaccination. METHODS HBV S genes were amplified by using polymerase chain reaction (PCR) and DNA sequence analysis of the "a" determinant was performed on sera from 30 childhood patients with immunoprophylaxis and 30 patients without vaccinations. RESULTS Mutations of the "a" determinant were… CONTINUE READING