• Corpus ID: 22725366

[Detection of chloropyridinyl neonicotinoid insecticide metabolite 6-chloronicotinic acid in the urine: six cases with subacute nicotinic symptoms].

  title={[Detection of chloropyridinyl neonicotinoid insecticide metabolite 6-chloronicotinic acid in the urine: six cases with subacute nicotinic symptoms].},
  author={Kumiko Taira and Yoshiko Aoyama and Tomonori Kawakami and Motoyuki Kamata and Toru Aoi},
  journal={Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology},
  volume={24 3},
  • K. TairaY. Aoyama T. Aoi
  • Published 1 September 2011
  • Medicine
  • Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology
Neonicotinoid is a recently developed insecticide with worldwide use that has been increasing. It acts as a nicotinic acetylcholine receptor agonist. Chloropyridinyl neonicotinoid is a subgroup of neonicotinoid, and are commercially available as imidacloprid, nitenpyram, acetamiprid, and thiacloprid. The maximum residue limits of acetamiprid for fruits and tea leaves are high in Japan, e.g. 5 ppm for grapes and 30 ppm for tea leaves. 6-chloronicotinic acid (6 CNA) is a common metabolite in… 

Figures and Tables from this paper

Human neonicotinoids exposure in Japan

In Japan, there are currently seven neonicotinoid (NN) insecticides, e.g. acetemiprid, since 1992 registration of imidacloprid, and the amount of domestic shipment of NNs was 407t in 2009, which is high compared to the rest of the world.

Instructions for use Title Contamination by neonicotinoid insecticides and their metabolites in Sri Lankan black tea leaves and Japanese green tealeaves

Tea is one of the world’s most popular beverages due to health promoting effects. Despite these, there have been concerns about the adverse effects of tea contamination by neonicotinoid insecticides.

Interspecies differences in cytochrome P450-mediated metabolism of neonicotinoids among cats, dogs, rats, and humans.

Relationship between Urinary N-Desmethyl-Acetamiprid and Typical Symptoms including Neurological Findings: A Prevalence Case-Control Study

Urinary N-desmethyl-acetamiprid can be used as a biomarker for environmental exposure to acetamipid and was associated with increased prevalence of the symptoms by a prevalence case-control study.

Qualitative Profiling and Quantification of Neonicotinoid Metabolites in Human Urine by Liquid Chromatography Coupled with Mass Spectrometry

Urinary N-desmethyl-acetamiprid, as well as 5-hydroxy-Imidacloprid and N- Desmethyl-clothianidin, may be a good biomarker for neonicotinoid exposure in humans and warrants further investigation.

A critical review on the potential impacts of neonicotinoid insecticide use: current knowledge of environmental fate, toxicity, and implications for human health.

Due to the heavy use of neonicotinoid insecticides and potential for cumulative chronic exposure, these insecticides represent novel risks and necessitate further study to fully understand their risks to humans.

Neurotoxic Effects of Neonicotinoids on Mammals: What Is There beyond the Activation of Nicotinic Acetylcholine Receptors?—A Systematic Review

Although neonicotinoids are considered safe, their presence in the environment could increase the risk of exposure and toxicity, and the large quantity, variety, and ubiquity of these receptors, combined with its diversity of functions, raises the question of what effects these insecticides can produce in non-target species.

Acetamiprid Accumulates in Different Amounts in Murine Brain Regions

Exposure to ACE-containing water for three or seven days (decuple and centuple of no observable adverse effect level (NOAEL)/day) caused a decrease in body weight in 10-week old A/JJmsSlc (A/J) mice, however, the treatments did not affect brain histology or expression of CD34.



Chloropyridinyl neonicotinoid insecticides: diverse molecular substituents contribute to facile metabolism in mice.

Persistence in the tissues was greater for ACE than the other neonicotinoids and Urinary excretion of the parent compound was greatest with NIT and IMI.

Unique and common metabolites of thiamethoxam, clothianidin, and dinotefuran in mice.

The diversity of biodegradable sites and multiple pathways insures against parent compound accumulation but provides intermediates reported to be active as nicotinic agonists and inducible nitric oxide synthase inhibitors.

Neonicotinoid insecticide toxicology: mechanisms of selective action.

The neonicotinoids have outstanding potency and systemic action for crop protection against piercing-sucking pests, and they are highly effective for flea control on cats and dogs.

Comparative metabolism and pharmacokinetics of seven neonicotinoid insecticides in spinach.

The metabolism of seven commercial neonicotinoid insecticides was compared in spinach seedlings (Spinacia oleracea) using HPLC-DAD and LC-MSD to analyze the large number and great variety of

Neonicotinoid insecticides: an emerging cause of acute pesticide poisoning

Significant toxicity of neonicotinoid insecticides can occur following large amount of oral ingestion, and judicious use of atropine seems justified in clinical management.

Monitoring of 6-chloronicotinic acid in human urine by gas chromatography-tandem mass spectrometry as indicator of exposure to the pesticide imidacloprid.

A new analytical method for determining 6-chloronicotinic acid (6-ClNA) in human urine is proposed and it is revealed that the influence of pH in the extraction process revealed that it affects the analyte extraction efficiency.

Applied aspects of neonicotinoid uses in crop protection.

New formulations have been developed to optimize the bioavailability of neonicotinoids through improved rain fastness, better retention and spreading of the spray deposit on the leaf surface, combined with higher leaf penetration, which will turn neonic nicotine into the most important chemical class in crop protection within the next few years.

Abnormal Foraging Behavior Induced by Sublethal Dosage of Imidacloprid in the Honey Bee (Hymenoptera: Apidae)

It is demonstrated that sublethal dosages of imidacloprid were able to affect foraging behavior of honey bees and showed abnormalities in revisiting the feeding site.

Pesticide residues in domestic agricultural products monitored in Hyogo Prefecture, Japan, FY 1995–2009

During a 15-year monitoring survey (April 1995–March 2010) of pesticide residues in agricultural products, 1542 domestic samples (cereals, vegetables, fruits, etc.) collected in Hyogo prefecture,