Corpus ID: 22137598

[Depletion of O6-alkylguanine alkyltransferase and chromosome damage induced by cisplatin, ning xin platin and carboplatin].

@article{Wang1991DepletionOO,
  title={[Depletion of O6-alkylguanine alkyltransferase and chromosome damage induced by cisplatin, ning xin platin and carboplatin].},
  author={L. Wang and X. Liu and P. Fan and X. Ji},
  journal={Yao xue xue bao = Acta pharmaceutica Sinica},
  year={1991},
  volume={26 8},
  pages={
          561-6
        }
}
  • L. Wang, X. Liu, +1 author X. Ji
  • Published 1991
  • Chemistry, Medicine
  • Yao xue xue bao = Acta pharmaceutica Sinica
O6-Alkylguanine-DNA-alkyltransferase (O6-AGT) is a very important DNA repair protein known to carry out the transfer of alkyl groups from the O6 position of guanine in alkylated DNA to a cysteine acceptor site contained within its own protein sequence. In this work, the activity of O6-AGT in different cell lines and the relationship between the depletion of the enzyme and the frequency of micronuclei induced by cisplatin (DDP), Ning Xin platin (camphoramine chloroacetic platinum, CCP) or… Expand