[Demonstration of molecular forms of Rap 1 in cells or tissues deriving from normal or pathological human colonic epithelium].

@article{Hilairet1995DemonstrationOM,
  title={[Demonstration of molecular forms of Rap 1 in cells or tissues deriving from normal or pathological human colonic epithelium].},
  author={Sandrine Hilairet and Michel Chignard Philippe and Thierry Janet and F Bonneau-Herv{\'e} and Philippe Babin and J. M. Muller},
  journal={Comptes rendus des seances de la Societe de biologie et de ses filiales},
  year={1995},
  volume={189 1},
  pages={127-40}
}
Mutations of the cK-ras gene which confer oncogenic properties to the corresponding encoded small G protein, occur in 30 to 50% of the human colonic adenocarcinomas. Overexpression of Rap 1A, a member of the Ras family, in K-ras transformed fibroblasts, reverts the transforming properties of the oncogene. This indicates that Rap 1A may exert antagonistic… CONTINUE READING