[Deletions and aberrant transcription of p16 and p15 genes in childhood acute lymphoblastic leukemia].


OBJECTIVE To explore the role of p16(MTS1) and p15(MTS2) genes in the pathogenesis of childhood acute lymphoblastic leukemia(ALL). METHODS PCR and Southern blot were used to analyse p16 and p15 gene deletions, RT-PCR was used to analyse p15 gene transcription. RESULTS Exon 1 and 2 of p16 gene deletion was detected in 8 of 21 patients(38.1%), and exon 1… (More)


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