[De novo cancer and adenoma-carcinoma sequence of the colorectum--clinicopathological differences between de novo carcinoma and carcinoma with the sequence].

Abstract

The adenoma-carcinoma sequence ("The great majority of colorectal carcinomas arises from adenomas") proposed by Morson et al (1972) has been generally accepted world wide. Considering the sequence from the viewpoint of human carcinogenesis in general, however, a few contradictions and mysterious phenomena are found in the development and growth process of… (More)

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