[D-penicillamine--side effects, pathogenesis and decreasing the risks].

  title={[D-penicillamine--side effects, pathogenesis and decreasing the risks].},
  author={K Grasedyck},
  journal={Zeitschrift fur Rheumatologie},
  volume={47 Suppl 1},
  • K Grasedyck
  • Published 1988 in Zeitschrift fur Rheumatologie
D-penicillamine (DPA) leads to side effects in different ways: collagen and elastin crosslinking are inhibited, which results in thin and vulnerable skin, cutis laxa, elastosis perforans serpiginosa, wound healing defects and embryopathy. Toxic influences effect thrombo- and leukocytopenia (incidence 5-15%), gastrointestinal disturbances (10-30%), changes or loss of taste (5-30%), loss of hair (1-2%), and partly proteinuria (5-20%). Acute hypersensitive reactions include DPA-allergy (2-10… CONTINUE READING


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