[Cytological analysis of the reaction of the nucleolar RNA and RNA-binding proteins to oxidative stress in HeLa cells].

@article{Mironova2014CytologicalAO,
  title={[Cytological analysis of the reaction of the nucleolar RNA and RNA-binding proteins to oxidative stress in HeLa cells].},
  author={A. A. Mironova and Natalia V. Barykina and Olga V. Zatsepina},
  journal={Tsitologiia},
  year={2014},
  volume={56 7},
  pages={489-99}
}
The organization and functional activity of the nucleoli of mammalian cells can be modified in response to various stress factors. However, data on the reaction of nucleoli to oxidative stress remain limited. In this paper, we have studied the localization of nucleolar RNAs and two RNA-binding proteins--fibrillarin, a pre-rRNA processing factor, and nucleophosmin/B23, a pre-ribosome assembly factor, in HeLa cells exposed to 1 mM H2O2 up to four hours. We have shown that under the conditions… CONTINUE READING
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