Corpus ID: 24113581

[Cultures of fetal bone sites as a model for studying drug influence on mesenchymal metabolic processes (author's transl)].

@article{Karzel1979CulturesOF,
  title={[Cultures of fetal bone sites as a model for studying drug influence on mesenchymal metabolic processes (author's transl)].},
  author={K. Karzel and K. Frey and K. Lee and U. Lippert},
  journal={Arzneimittel-Forschung},
  year={1979},
  volume={29 12},
  pages={
          1823-8
        }
}
Cultures of murine embryonic bone explants were studied regarding their use as experimental model for the investigation of drug effects on metabolic processes of mesenchymal tissues. Embryonic tibiae excised on the 17th day of gestation and grown in a liquid medium for 6 days as organ cultures appeared particularly suited for this purpose. The planimetrically estimated size of the explants increased during this period in the mean by 40.7% and their DNA-content rose by 67.5%. After 6 days of… Expand