• Corpus ID: 34870762

[Cross-reacting HLA antigens as a factor increasing the risk of childlessness in a family].

@article{Montag1993CrossreactingHA,
  title={[Cross-reacting HLA antigens as a factor increasing the risk of childlessness in a family].},
  author={Thomas Montag and Georgiy N. Drannik and I. I. Gorpinchenko and L A Bystrov and M. N. Sokolova and S. N. Vashchenko},
  journal={Likars'ka sprava},
  year={1993},
  volume={4},
  pages={
          86-90
        }
}
A comparative analysis of HLA phenotypes of fertile and infertile spouses revealed that among the infertile the sum of spouses showed compatibility in two or three HLA antigens. A detailed analysis also showed that 10 infertile couples exhibited identical and 2 antigens with a similar structure and function with so-called cross-reactions increasing the histocompatibility index to 75%. The significance of these facts for infertility risk factors is discussed. 
HLA‐A2 class I antigens in couples with recurrent spontaneous abortions
TLDR
It can be suggested that the HLA‐A2 molecule, in context with specific genotypes, may contribute to the overall maternal immune response in normal and disturbed pregnancy.