[Critical analysis of the ISUIA study: the methodological point of view].


ISUIA is a prospective study that ran from 1991 to 1998 and included 4060 patients from 161 centers. Analysis of the methodology focused on: (1) sampling: inclusion was more intensive towards the end of the study period, which was likely to generate a selection bias; (2) a possible indication bias, as direct comparison between observation and treatment… (More)
DOI: 10.1016/j.neurad.2007.11.003


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