[Correlation of quantification of major bcr-abl mRNA between TMA (transcription mediated amplification) method and real-time quantitative PCR].

@article{Yagasaki2009CorrelationOQ,
  title={[Correlation of quantification of major bcr-abl mRNA between TMA (transcription mediated amplification) method and real-time quantitative PCR].},
  author={Fumiharu Yagasaki and Toshihiro Niwa and Aki Abe and Maho Ishikawa and Chiaki Kato and Kenji Ogura and Hiroshi Sasaki and Taiichi Kyo and Ituroh Jinnai and Masami Bessyo and Kouichi Miyamura},
  journal={[Rinsho ketsueki] The Japanese journal of clinical hematology},
  year={2009},
  volume={50 6},
  pages={481-7}
}
Imatinib mesylate has significantly improved the outcome of patients with CML. In the IRIS trial, major molecular response (MMR), which is defined as the achievement of > or =3 log reduction in bcr-abl mRNA from the standardized baseline, was observed in 40% of CML patients by 12 months. Achievement of an MMR at 18 months is associated with 100% probability of transformation-free survival at 60 months, and MMR is an important goal of therapy. The nucleic acid quantitative "DNA probe FR Amp-CML… CONTINUE READING
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