[Correlation of high expression of HSP27 to multidrug resistance of leukemia cell line K562/VCR].

Abstract

BACKGROUND & OBJECTIVE Multidrug resistance (MDR) is a major obstacle preventing effective treatment of leukemia. The mechanisms of MDR in leukemic cells have been broadly explored, but they are still unclear. We used proteomic tools to screen MDR-related proteins in vincristine-resistant leukemia cell line K562/VCR, and analyzed the mechanism of MDR in… (More)

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