[Correlation of genetic polymorphisms in DNA repair genes ADPRT and XRCC1 to risk of gastric cancer].

@article{Zhang2006CorrelationOG,
  title={[Correlation of genetic polymorphisms in DNA repair genes ADPRT and XRCC1 to risk of gastric cancer].},
  author={Zhi F. Zhang and Xiao-ping Miao and Wen Tan and Yong-li Guo and Xuemei Zhang and Dong-xin Lin},
  journal={Ai zheng = Aizheng = Chinese journal of cancer},
  year={2006},
  volume={25 1},
  pages={7-10}
}
BACKGROUND & OBJECTIVE Adenosine diphosphate ribosyl transferase (ADPRT) and X-ray repair cross-complementing 1 (XRCC1) are 2 major DNA base excision repair (BER) proteins and act interactively in stimulating and executing BER processes. Polymorphisms of ADPRT 762Val-->Ala and XRCC1 399Arg-->Gln have been verified to associate with altered protein function and BER activity. This study was to examine the contribution of these 2 polymorphisms, alone or in combination, to the risk of developing… CONTINUE READING

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