[Correlation of 53BP1 and p53 polymorphisms to susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma].

@article{Cao2007CorrelationO5,
  title={[Correlation of 53BP1 and p53 polymorphisms to susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma].},
  author={Yan-yan Cao and Hui Ge and Long-Qi Chen and Zhi-Feng Chen and Deng-gui Wen and Yan Li and Jianhui Zhang},
  journal={Ai zheng = Aizheng = Chinese journal of cancer},
  year={2007},
  volume={26 10},
  pages={1052-7}
}
BACKGROUND & OBJECTIVE 53BP1 is one of p53-binding proteins, which can enhance the transcriptional activation of p53 and plays a key role in tumor suppression. A single nucleotide polymorphism (SNP) T885G has been found in the promoter of 53BP1. This study was to investigate the correlation of 53BP1 and p53 SNPs to susceptibility to esophageal squamous cell carcinoma (ESCC) and gastric cardiac adenocarcinoma (GCA) in a high incidence area of Hebei Province in China. METHODS Genotypes of 53BP1… CONTINUE READING

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