[Correlation between methylation of 5'-CpG islands and inactivation of FHIT gene in cervical cancer].

@article{Shi2005CorrelationBM,
  title={[Correlation between methylation of 5'-CpG islands and inactivation of FHIT gene in cervical cancer].},
  author={Hui-rong Shi and Qing-hua Wu and Zhen-he Suo and Jahn Martin Nesland},
  journal={Ai zheng = Aizheng = Chinese journal of cancer},
  year={2005},
  volume={24 1},
  pages={7-11}
}
BACKGROUND & OBJECTIVE Fragile histidine triad (FHIT) gene, a tumor suppressor gene, correlates with tumorigenesis of many solid tumors, and may be inactivated via methylation. This study was designed to explore relationship of methylation of 5'-CpG islands with inactivation of FHIT gene in cervical cancer. METHODS Methylation of 5'-CpG islands in 10 normal cervical squamous epithelial tissues, and 40 cervical cancer tissues was detected with methylation specific polymerase chain reaction… CONTINUE READING

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