[Construction of optimal alignment of two amino acid sequences: a solution of the problem of unnecessary gaps].

Abstract

A computing method for calculation of total similarity of two amino acid sequences depending on the number of gaps introduced into these sequences has been developed. It was based on Needleman--Wunsch--Sankoff's principles. The application of the method to randomized sequences enables us to select the optimal alignment of real sequences, in which the number… (More)

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