[Construction and identification of recombinant retroviral vector containing human interleukin 1 receptor antagonist and its expression in osteoarthritic human articular chondrocytes].

Abstract

OBJECTIVE To construct the retroviral vector containing human interleukin 1 receptor antagonist (IL-1Ra) and to investigate the property of the transfected articular chondrocytes from osteoarthritic patients in vitro. METHODS Retroviral vector PLXRN carrying IL-1Ra (PLXRN-IL-1Ra) gene was constructed by inserting IL-1Ra gene at the sites of Sal I and BamH… (More)

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