[Congenital hemolytic anemia--hemoglobin abnormality--thalassemia].

@article{Fujita1996CongenitalHA,
  title={[Congenital hemolytic anemia--hemoglobin abnormality--thalassemia].},
  author={Shin-ichi Fujita},
  journal={Nihon rinsho. Japanese journal of clinical medicine},
  year={1996},
  volume={54 9},
  pages={2454-9}
}
Thalassemias are a group of genetic disorders caused by unbalanced synthesis of alpha- and non-alpha chains of globins due to impaired globin genes. Clinical characteristics of the thalassemias are ineffective erythropoiesis and hemolytic anemia with microcytic-hypochromic erythrocytes. Surplus polypeptide chain synthesized by normal globin gene causes harmful effects to skeleton proteins of erythrocyte membrane, such as spectrin, ankirin and 4.1 protein, via a few different ways and normal… CONTINUE READING