[Comparison of the brain pharmacokinetics of nasal tetramethylpyrazine phosphate pH-sensitive in situ gel in normal rats and model rats].

Abstract

The study is to investigate the brain pharmacokinetics change of nasal tetramethylpyrazine phosphate (TMPP) pH-sensitive in situ gel in normal and model rats. Acute cerebral ischemia rat model was successfully established by middle cerebral artery occlusion (MCAO) method. Both normal and model rats were given nasal TMPP pH-sensitive in situ gel (10 mg x kg… (More)

Topics

Cite this paper

@article{Liu2012ComparisonOT, title={[Comparison of the brain pharmacokinetics of nasal tetramethylpyrazine phosphate pH-sensitive in situ gel in normal rats and model rats].}, author={Hongwei Liu and Yi-Lin Yan and Li-ling Zhou}, journal={Yao xue xue bao = Acta pharmaceutica Sinica}, year={2012}, volume={47 5}, pages={677-9} }