[Comparative thermodynamic analysis of thrombin interaction with anti-thrombin aptamers and their heterodimeric construct].

Abstract

Aptamers interacting selectively with the anion-binding exosites 1 and 2 of thrombin were merged into dimeric oligonucleotide constructs with use of a poly-(dT)-linker of 35 nucleotides (nt) long. Complexes of thrombin with the aptamers and their hetero- and homodimeric constructs were measured using the optical biosensor Biacore-3000. K(D) values measured… (More)

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@article{Rakhmetova2010ComparativeTA, title={[Comparative thermodynamic analysis of thrombin interaction with anti-thrombin aptamers and their heterodimeric construct].}, author={S Iu Rakhmetova and Sergei Rad'ko and Oksana V. Gnedenko and Nikolay V Bodoev and A. S. Ivanov and A. I. Archakov}, journal={Biomeditsinskaia khimiia}, year={2010}, volume={56 3}, pages={405-12} }