[Comparative studies on antiviral activity of several TDA analogs against HSV-2].

@article{Yin1986ComparativeSO,
  title={[Comparative studies on antiviral activity of several TDA analogs against HSV-2].},
  author={Ming-biao Yin and Yong Jun Gao and Li Jun Xia and Ya-yan Liu and Lin Wang and Miao Xuan Chen and Huike Yang and Zheng Zhi Zhao},
  journal={Yao xue xue bao = Acta pharmaceutica Sinica},
  year={1986},
  volume={21 9},
  pages={
          657-62
        }
}
Fourteen TDA analogs were synthesized and their antiviral and cytotoxic activities examined. Among the 14 TDA analogs 6 were found to be effective against HSV-2. Of the 6 compounds V8540 was shown to be most potent inhibitor of HSV-2 in a plaque inhibition assay in Vero cells. It is approximately 10 times more active against HSV-2 than TDA. The following order of decreasing activity against HSV-2 in Vero cells was found: V8540V8512V8509V8502V8501V8519. The Other compounds were less effective or… CONTINUE READING

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