[Comparative in vitro and in vivo studies on the permeation and penetration of ketoprofen and ibuprofen in human skin].

@article{Bock2004ComparativeIV,
  title={[Comparative in vitro and in vivo studies on the permeation and penetration of ketoprofen and ibuprofen in human skin].},
  author={Udo Bock and Wendelin Krause and Joachim Otto and Eleonore Haltner},
  journal={Arzneimittel-Forschung},
  year={2004},
  volume={54 9},
  pages={522-9}
}
The aim of the present in vitro and in vivo studies was to compare the permeation and penetration of a 2.5% ketoprofen (CAS 22071-15-4) gel [Phardol Schmerz-Gel (Test-D)] with the permeation and penetration of two other ketoprofen gels (Ref-I, Ref-E) and an ibuprofen (CAS 15687-27-1) gel (Ref-D) on excised human skin. Furthermore, in vivo studies were performed. The permeation studies utilizing static Franz diffusion cells allow the determination of the transdermal (systemic) transport, whereas… CONTINUE READING