[Combined use of melatonin and low-dose flunitrazepam for treatment of sleep disturbance in a child with spastic quadriplegia: evaluation using polysomnography].

@article{Tanaka2002CombinedUO,
  title={[Combined use of melatonin and low-dose flunitrazepam for treatment of sleep disturbance in a child with spastic quadriplegia: evaluation using polysomnography].},
  author={Hajime Tanaka and Satomi Kakutani and Akiko Araki and Ikue Fukuda and Ryuji Oka and Kazuhiko Cho},
  journal={No to hattatsu = Brain and development},
  year={2002},
  volume={34 6},
  pages={528-32}
}
A 14-year-old boy born at 39 gestational weeks with the birth weight of 3,250 g, had severe mental retardation and spastic quadriplegia of unknown etiology from early childhood. At 7 years of age, disturbance of night sleep appeared with several awakenings. Combined treatment with melatonin (MLT; 0.04 mg/kg) and flunitrazepam (FNZ; 0.025 mg/kg) was more effective than monotherapy with FNZ for the sleep disturbance. Difference of the effects of the combined therapy and the monotherapy for the… CONTINUE READING