[Combined inhibition of Stat3 and HIF-1α for enhancement of radio- and chemo-sensitivity in laryngeal squamous cell carcinoma].

Abstract

OBJECTIVE To investigate the influence of signal transducer and activator of transcription 3 (Stat3) and hypoxia-inducible factor-lα (HIF-1α) on the resistance effect of laryngeal squamous cell carcinoma to radiation therapy and chemotherapy under the hypoxia circumstances. METHOD Western blot was used to test the expression of p-Stat3 and HIF-1α in the… (More)

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