[Combined estrogenic activity of soybean extract used in a dietary supplement and ethinyl estradiol].

@article{Kawazoe2010CombinedEA,
  title={[Combined estrogenic activity of soybean extract used in a dietary supplement and ethinyl estradiol].},
  author={Sadahiro Kawazoe and Kazuna Naka and Hiroshi Ishibashi and Tomomi Obara and Koji Arizono and Kaori Hashimoto and Yasuji Hojo and Takashi Suzuki},
  journal={Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan},
  year={2010},
  volume={51 3},
  pages={
          101-9
        }
}
We examined the combined estrogenic activity of soybean extract used in a dietary supplement and ethinyl estradiol (EE) contained in an oral contraceptive. Olive oil (control), soybean extract (0.0036 or 0.36 g/kg corresponding to doses of total isoflavone of 0.83 or 83 mg/kg respectively), EE (1 or 10 microg/kg), and soybean extract+EE were administered to ovariectomized CD-1 mice by oral gavage for 4 consecutive days. Soybean extract (0.0036 or 0.36 g/kg) and EE (1 microg/kg) did not increase… 
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Do extracts of oral soybean augment the trophic effect of estrogen on the rat uterus?
TLDR
The results indicate that soy extract has a trophic effect on rat uterine structures, and treatment of ovariectomized rats with a concentrated soy extract in combination with conjugated estrogens had no addictive effect on the uterine response.

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