[Clinicopathologic features of aggressive natural killer cell leukemia].

  title={[Clinicopathologic features of aggressive natural killer cell leukemia].},
  author={En-bin Liu and Hui-shu Chen and Pei-hong Zhang and Zhanqi Li and Qi Sun and Qing-ying Yang and Li-huan Fang and Fu-jun Sun},
  journal={Zhonghua bing li xue za zhi = Chinese journal of pathology},
  volume={40 12},
  • E. Liu, Hui-shu Chen, Fu-jun Sun
  • Published 1 December 2011
  • Medicine, Biology
  • Zhonghua bing li xue za zhi = Chinese journal of pathology
OBJECTIVE To study the clinicopathologic features of aggressive natural killer cell leukemia (ANKL). METHODS The clinical and pathologic features were analyzed in 10 patients with ANKL. The complete blood count, peripheral blood smears, bone marrow aspirates and bone marrow biopsies were studied. Immunophenotypic analysis was carried out by flow cytometry and immunohistochemistry. T-cell receptor (TCR) γ gene rearrangement was studied by PCR method. RESULTS The most frequent hematologic… 
Aggressive mature natural killer cell neoplasms: from epidemiology to diagnosis
  • M. Lima
  • Medicine
    Orphanet Journal of Rare Diseases
  • 2013
The rarity of the NK-cell tumors limits the ability to standardiz procedures for the diagnosis and clinical management and efforts should be made to encourage multi-institutional registries.
Extranodal NK/T cell lymphoma and aggressive NK cell leukaemia: evidence for their origin on CD56+bright CD16−/+dim NK cells
  • M. Lima
  • Medicine, Biology
  • 2015
P phenotypic features would suggest that ENKTL and ANKL cells do represent the neoplastic counterpart of the mature CD56+bright NK cells, which undergo activation and malignant transformation after Epstein–Barr virus infection.