[Clinical significance of hypoxia inducible factor-prolyl hydroxylase 1 and factor inhibiting hypoxia inducible factor-1 expression in placentas of women with severe pre-eclampsia].


OBJECTIVE To investigate the role of hypoxia inducible factor (HIF)-prolyl hydroxylase 1 (HPH1) and factor inhibiting HIF-1 (FIH-1) in placentas in the pathogenesis and development of severe pre-eclampsia. METHODS RT-PCR and western blot analyses were used to detect the HPH1 and FIH-1 expression levels in placentas of 34 patients with severe pre-eclampsia… (More)


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