[Clinical pharmacokinetics of cis-diamminedichloroplatinum (DDP)].

  • Meng-li Zhang
  • Published 1992 in
    Zhonghua zhong liu za zhi [Chinese journal of…


We studied the pharmacokinetics of DDP in 9 cancer patients who received iv infusion of DDP (100-120 mg/m2). Platinum concentration was measured by high performance liquid chromatography (HPLC). Plasma clearance of platinum was biphasic. There was a short initial phase with a half life of 19.8 min and a long second phase with a half life of 41.13 hours. A… (More)


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