[Clinical and cytogenetic analysis of 257 cases of Down's syndrome].

@article{Astete1991ClinicalAC,
  title={[Clinical and cytogenetic analysis of 257 cases of Down's syndrome].},
  author={C Astete and Ronald Youlton and Sergio M Castillo and Cecilia Be and V Daher},
  journal={Revista chilena de pediatria},
  year={1991},
  volume={62 2},
  pages={99-102}
}
Among 257 patients with clinical diagnosis of Down's syndrome, 56.4% of male gender, in whom cytogenetic studies were performed, 14 (5.4%) had normal karyotypes and 243 (94.6%) had 21 trisomy. Of these last, 225 (92.6%) had free 21 trisomy, 10 (4.1%) showed mosaics, 8 (3.3%) had translocations. Average maternal age of this sample was significantly higher than that of patients attending the same maternity wards (32.14 vs. 24.85 years) and 41% of Down syndrome's patients came from mothers aged 36… CONTINUE READING