[Ciradian variation in the lethal dose 50 of mercuric chloride in mice].

@article{Cambar1982CiradianVI,
  title={[Ciradian variation in the lethal dose 50 of mercuric chloride in mice].},
  author={Jean Cambar and J C Cal},
  journal={Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie},
  year={1982},
  volume={294 3},
  pages={149-52}
}
If circadian variations in tolerance to drugs have been often demonstrated, such observations about heavy metals are still very scarce. The present study proposes to determine if circadian variations occur in the tolerance of Mice to single lethal dose of mercuric chloride. 360 female Mice, kept in cages on a 8.00 - 20.00 L/D cycle, receive I.P. a single mercuric chloride injection at different concentrations (100 to 300 X 10(-6)) at different hours in the day (8.00 - 14.00 - 20.00 or 2.00… CONTINUE READING