[Ciclesonid--new generation of inhaled glucocorticosteroid].

  title={[Ciclesonid--new generation of inhaled glucocorticosteroid].},
  author={Andrzej Chciałowski and Tadeusz Płusa},
  journal={Wiadomosci lekarskie},
  volume={57 1-2},
Inhaled corticosteroids with long acting beta 2-mimetics have become the mainstay of therapy for patients with asthma. The clinical and biological activity of the inhaled corticosteroids expressed as anti-inflammatory effect depends on their bioavailability, receptor affinity, lipophility, half-life terminal elimination and molecule value. Ciclesonide as a novel corticosteroid itself is inactive and used as prodrug form and needs to be cleaved by pulmonary esterases to acquire anti-inflammatory… CONTINUE READING