[Chronic ethanol feeding induces oxidative stress in the rat retina: treatment with the antioxidant ebselen].

@article{JohnsenSoriano2007ChronicEF,
  title={[Chronic ethanol feeding induces oxidative stress in the rat retina: treatment with the antioxidant ebselen].},
  author={Siv Johnsen-Soriano and Jos{\'e} M Genov{\'e}s and Bel{\'e}n Romero and Salvador Garc{\'i}a-Delpech and Mar{\'i}a Muriach and M. Sancho-Tello and Francisco Bosch-Morell and Francisco Javier Romero},
  journal={Archivos de la Sociedad Espanola de Oftalmologia},
  year={2007},
  volume={82 12},
  pages={757-62}
}
PURPOSE To assess the involvement of biochemical and functional changes to the retina after chronic ethanol intake in adult rats, and the capacity of the antioxidant ebselen to prevent these changes. METHODS Male Sprague-Dawley rats were used in the study. They were fed an ethanol-containing liquid diet, whereas a control group was given an ethanol-free isocaloric diet. After six weeks of experiment, the eyes were extracted and homogenized without the lens, and markers of oxidative stress… CONTINUE READING