Corpus ID: 34603765

[Cholinomimetic activity of acetylcholine and sebacinyldicholine derivatives with differing cationic group structures].

@article{KhromovBorisov1975CholinomimeticAO,
  title={[Cholinomimetic activity of acetylcholine and sebacinyldicholine derivatives with differing cationic group structures].},
  author={N. V. Khromov‐Borisov and A. Danilov and M. L. Indenbom and L. P. Tikhonova and V. V. Lavrent'eva},
  journal={Farmakologiia i toksikologiia},
  year={1975},
  volume={38 6},
  pages={
          683-7
        }
}
  • N. V. Khromov‐Borisov, A. Danilov, +2 authors V. V. Lavrent'eva
  • Published 1975
  • Chemistry, Medicine
  • Farmakologiia i toksikologiia
  • The intrinsic alpha activities and the D2 (frog, m, rectus abdominalis) concentrations were estimated for different acetylcholine and sebacinylcholine derivatives. So were also the A2 values for antagonists and the affinity constants Kc for some partial agonists. The results obtained disprove Paton's "rate-theory". The relationship between the cholinergic activity and the volume of cationic groups was studied and it could not possibly be explained by the steric hindrance alone. It is suggested… CONTINUE READING

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