[Characterization the immunogenicity of recombinant VP2 of infectious bursal disease virus containing N-terminal M2e of avian influenza virus].

@article{Tang2012CharacterizationTI,
  title={[Characterization the immunogenicity of recombinant VP2 of infectious bursal disease virus containing N-terminal M2e of avian influenza virus].},
  author={Yinghua Tang and Yuzhen Gong and Yongwei Wang and Jihu Lu and Peipei Wu and Feng Gao and Tao Chen and Jiahui He and Jibo Hou},
  journal={Wei sheng wu xue bao = Acta microbiologica Sinica},
  year={2012},
  volume={52 6},
  pages={753-9}
}
OBJECTIVE We developed subunit vaccines against H5 or H9 subtype avian influenza viruses (AIV) and infectious bursal disease viruses (IBDV). Viral protein 2 (VP2) of IBDV was used as cargo protein to display a 12-amino-acid (aa) immunodominant epitope derived from N-terminal M2 extracelluar domain (nM2e) of H5 or H9 subtype AIV. METHODS The aa and nucleotide sequence of nM2e was determined by comparing the available avian influenza vaccine strains and alignment the AIV sequence available in… CONTINUE READING