• Corpus ID: 24251977

[Characterization of an endogenous factor with digitalis-like activity in the heart of the guinea pig (I): Inhibition of Na,K-ATPase)].

@article{CastaedaHernndez1987CharacterizationOA,
  title={[Characterization of an endogenous factor with digitalis-like activity in the heart of the guinea pig (I): Inhibition of Na,K-ATPase)].},
  author={Gilberto Casta{\~n}eda Hern{\'a}ndez},
  journal={Archivos del Instituto de Cardiologia de Mexico},
  year={1987},
  volume={57 2},
  pages={
          97-101
        }
}
The purpose of this work is to study the presence of an endogenous inhibitor of the sodium pump in mammals. A water extract was prepared from guinea pig heart and partially purified by liquid chromatography. The extract inhibited the activity of Na,K-ATPase but had no effect on Mg-ATPase nor on Ca-ATPase. The inhibition was similar to that produced by cardiac glycosides since it was dose-dependent, antagonised by potassium and the Na,K-ATPase prepared from brain was more sensitive than the one…