• Corpus ID: 23366552

[Changes in plasma cortisol and ACTH caused by diazepam, bromazepam, triazolam, and alprazolam in oral premedication].

@article{RodrguezHuertas1992ChangesIP,
  title={[Changes in plasma cortisol and ACTH caused by diazepam, bromazepam, triazolam, and alprazolam in oral premedication].},
  author={F. Rodr{\'i}guez-Huertas and M. S. Carrasco and A. Garc{\'i}a-Baquero and F. D. Coq and J. Freire},
  journal={Revista espanola de anestesiologia y reanimacion},
  year={1992},
  volume={39 3},
  pages={
          145-8
        }
}
INTRODUCTION Benzodiazepines relieve anxiety and modify the endocrine response to surgical-anesthetic stress. OBJECTIVES The aim of this study was to evaluate the effects of four benzodiazepines on preoperative secretion of cortisol and ACTH. MATERIAL AND METHODS We studied 60 patients programmed for abdominal surgery. Patients were randomly allocated into six groups of treatment: control group (placebo), diazepam 10 mg, triazolam 0.5 mg, alprazolam 0.5 mg, bromazepam 6 mg, and bromazepam… 
Interdose Elevation in Plasma Cortisol During Chronic Treatment with Alprazolam but not Lorazepam in the Elderly
TLDR
It is suggested that even a short period of chronic treatment with alprazolam, but not lorazepam, may result in interdose HPA axis activation in the elderly, consistent with drug withdrawal, and this effect may contribute to an increased risk for drug escalation and dependence during chronic alpazolam treatment.
Cortisol response to diazepam: its relationship to age, dose, duration of treatment, and presence of generalized anxiety disorder
TLDR
Diazepam reduced cortisol both acutely and during chronic treatment, but not during final challenge, consistent with some tolerance development, most apparent in the elderly compared with the young adults.
Oral Diazepam effect on surgical patient's postoperative blood sugar
TLDR
Using oral Diazepam as a premedication drug attenuates the hyperglycemic response due to surgical stress-induced release of Catecholamine and Cortisol so the less hormonal changes, sooner patient discharge, fewer occupied beds in hospitals and less expenses for patients, hospital and health system.
Effect of diazepam on the immune response of rats exposed to acute and chronic swim stress.
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It is concluded that diazepam modifies the immune response of rats exposed to acute and chronic swim stress and lowered the suppressed proliferative response of the splenocytes to PHA found in non-trained swimmers.
Prämedikationsregime im Vergleich
TLDR
It is concluded that 50 mg CD the evening before surgery prevented an increase of anxiety and sympatho-adrenal activity in both groups and might therefore be sufficient as premedication.