Corpus ID: 5896027

[Change in Toll-like receptor 4 expression on interstitial macrophages in acute lung injury].

@article{Zhang2004ChangeIT,
  title={[Change in Toll-like receptor 4 expression on interstitial macrophages in acute lung injury].},
  author={Wei Zhang and Yaonan Jiang and Zhifen Xie and Feng-lin Lv and Cheng-Chun Hu and Lei Li},
  journal={Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue},
  year={2004},
  volume={16 10},
  pages={
          622-5
        }
}
  • W. Zhang, Yaonan Jiang, +3 authors L. Li
  • Published 2004
  • Medicine
  • Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
OBJECTIVE To observe changes in the level of Toll-like receptor 4 (TLR4) mRNA and the expression of TLR4 protein in interstitial macrophages in serious thoracic injury. METHODS A rat model of severe thoracic trauma was reproduced,then interstitial macrophages were isolated and collected by enzymatic digestion before and after trauma cultured. TLR4 mRNA and the expression of TLR4 protein were measured by Northern and Western blotting before trauma and 2, 4, 8, 16, 24 hours after trauma… Expand
1 Citations
5-Lipoxygenase Activating Protein (FLAP) Dependent Leukotriene Biosynthesis Inhibition (MK591) Attenuates Lipid A Endotoxin-Induced Inflammation
TLDR
Together, these data clarify the mechanistic association between 5-lipoxygenase activating protein-mediated leukotriene biosynthesis and 5-LO dependent eicosanoid metabolites in mediating the TLR-dependent inflammatory response after endotoxin exposure typical of bacterial sepsis. Expand