[Cerebrospinal fluid penetration of ofloxacin (Tarivid) in non-inflamed meninges].

In 9 patients, who underwent lumbar drainage after transsphenoidal surgery for pituitary adenoma, we collected 69 samples of CSF and plasma, respectively. The concentration of ofloxacin was measured bacteriologically. Considering the ofloxacin CSF and plasma levels related to time some aspects of pharmacokinetics are discussed. With maximum CSF… (More)