[Central serotonin receptors and chronic treatment with selective serotonin reuptake inhibitors in the rat: comparative effects of fluoxetine and paroxetine].

@article{Poul1995CentralSR,
  title={[Central serotonin receptors and chronic treatment with selective serotonin reuptake inhibitors in the rat: comparative effects of fluoxetine and paroxetine].},
  author={E Le Poul and Lucimey Lima and A. M. Laporte and Christian Even and Edith Doucet and C. M. Fattaccini and Nora Laaris and Michel Hamon and Laurence Lanfumey},
  journal={L'Encephale},
  year={1995},
  volume={21 2},
  pages={123-32}
}
The hypothesis that a dysfunction of serotonergic neurotransmission is implicated in depression is supported by the clinical efficiency of selective serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitors (SSRIs) in the treatment of depressive disorders. These drugs, such as fluoxetine and paroxetine, exert their antidepressant activity by increasing 5-HT concentration in the synaptic cleft and thus enhancing serotonergic neurotransmission. However, two to three weeks of treatment are… CONTINUE READING