[Central and peripheral interactions of the antiparkinson agent biperiden and the antihistaminic bamipin on the rat excited by pilocarpine].


Excitatory reactions elicited by pilocarpine HCl (50 mg/kg i.v. in 6 s) are used for demonstrating synergistic effects of the central anticholinergic drug biperiden (Akineton) and the antihistamine bamipine (Soventol). Scratching movements of the hind legs are used as parameter for central activity, salivation for peripheral and death for toxic drug effect… (More)


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