[Cardiovascular effect of intracerebroventricular injection of orexin-1 receptor antagonist in rats].

@article{Guo2010CardiovascularEO,
  title={[Cardiovascular effect of intracerebroventricular injection of orexin-1 receptor antagonist in rats].},
  author={Bao-Qiang Guo and Min Jia and Jin-Xu Liu and Zhao Zhang},
  journal={Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology},
  year={2010},
  volume={26 3},
  pages={278-83}
}
OBJECTIVE To study the cardiovascular effect of selective orexin-1 receptor (OX1R) antagonist SB408124 in anesthetized rats and explore the underlying mechanism by using intracerebroventricular (ICV) microinjection combined with immunohistochemical assay. METHODS The changes of mean arterial blood pressure (MAP) and heart rate (HR) of male Sprague-Dawley rats were recorded during ICV microinjection of SB408124 with or without pretreatment of atropine methyl nitrate or hexamethonium bromide… CONTINUE READING