[Carboxypeptidase-G2 administration after high-dose methotrexate. Treatment and drug interactions].

@article{CzarOlmo2009CarboxypeptidaseG2AA,
  title={[Carboxypeptidase-G2 administration after high-dose methotrexate. Treatment and drug interactions].},
  author={J A C{\'o}zar Olmo and C Mart{\'i}nez Colmenero and I Pel{\'a}ez Pleguezuelos and Isabel Leiva Gea and Ana Bel{\'e}n L{\'o}pez Garc{\'i}a and Jes{\'u}s de la Cruz Moreno},
  journal={Anales de pediatria},
  year={2009},
  volume={71 3},
  pages={
          230-4
        }
}
Methotrexate (MTX) is widely used as anticancer agent in various malignancies, including acute lymphoblastic leukaemia, lymphoma and osteosarcoma. High doses of MTX may cause acute renal dysfunction. Nephrotoxicity is prevented by the use of alkalinization and hydration. More recently Carboxypeptidase-G2, a recombinant bacterial enzyme that rapidly hydrolyzes MTX to inactive metabolites, has become available for the treatment of acute nephrotoxicity. On the other hand, glutamine is usually… Expand
1 Citations
Glucarpidase (voraxaze), a carboxypeptidase enzyme for methotrexate toxicity.
TLDR
Glucarpidase (Voraxaze) for methotrexate toxicity and its application in clinical practice is still under investigation. Expand

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TLDR
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TLDR
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TLDR
The time course and management of methotrexate (MTX) toxicity in a 14-year-old Hispanic boy with osteosarcoma treated with high-dose MTX is described, suggesting that MTX may be a cause of these complications. Expand
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TLDR
Bacterial enzyme carboxypeptidase‐G2 (CPDG2) hydrolyzes MTX into inactive metabolites and has been demonstrated to lower plasma MTX concentrations to nontoxic levels rapidly in the nonhuman primate after HDMTX infusion. Expand
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TLDR
A patient affected by an osteosarcoma, underwent life-threatening toxicities following the first course of HD-MTX and received two doses of CPDG2 as a specific rescue, and therapeutic drug monitoring was performed using an high-performance liquid chromatography method, since fluorescence polarization immunoassay became unreliable. Expand
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TLDR
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TLDR
The administration of HD-MTX has no direct tubulotoxic effect and the disturbance in glomerular function was dose dependently and indicated by an increase in proteinuria as well as by a decrease in GFR; all changes were completely reversible and did not correlate to the metabolism of MTX to 7-OH- MTX. Expand
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TLDR
These studies suggest that GLN supplementation is safe in its administration to the tumor-bearing host receiving MTX, and may serve to increase the therapeutic window of this chemotherapeutic age. Expand
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TLDR
The objectives of the current study were to estimate the current incidence of HDMTX‐induced renal dysfunction in patients with osteosarcoma and to compare the efficacy and recovery of renal function for dialysis‐based methods of MTX removal with treatment using CPDG2. Expand
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