[Can we prevent the progression of aortic valve sclerosis and stenosis? The need for a prospective, randomized trial].

@article{Scardi2005CanWP,
  title={[Can we prevent the progression of aortic valve sclerosis and stenosis? The need for a prospective, randomized trial].},
  author={Sabino Scardi and Antonella Cherubini},
  journal={Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology},
  year={2005},
  volume={6 7},
  pages={403-12}
}
Cardiologists long assumed that aortic valve sclerosis/stenosis is a wear-and-tear, degenerative process; recent studies suggested that lipoproteins can play a key role in the development of both sclerosis/stenosis in the aortic valve. Thus, sclerosis/stenosis cannot be considered as a simple degenerative process, but on the contrary it is complex and involves multiple pathogenetic mechanisms. Experimental, clinical and epidemiological data support the link between aortic valvulopathy and… CONTINUE READING

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Prospective trials in Canada and Europe are now ongoing ( ASTRONOMER -- Aortic Stenosis Progression Observation Measuring Effects of Rosuvastatin ; SEAS -- Simvastatin and the Ezetimibe in Aortic Stenosis ) and will address the use of cholesterol - lowering drugs in reducing the progression of aortic valve stenosis and in improving clinical outcomes .
Prospective trials in Canada and Europe are now ongoing ( ASTRONOMER -- Aortic Stenosis Progression Observation Measuring Effects of Rosuvastatin ; SEAS -- Simvastatin and the Ezetimibe in Aortic Stenosis ) and will address the use of cholesterol - lowering drugs in reducing the progression of aortic valve stenosis and in improving clinical outcomes .
Cardiologists long assumed that aortic valve sclerosis / stenosis is a wear - and - tear , degenerative process ; recent studies suggested that lipoproteins can play a key role in the development of both sclerosis / stenosis in the aortic valve .
Cardiologists long assumed that aortic valve sclerosis / stenosis is a wear - and - tear , degenerative process ; recent studies suggested that lipoproteins can play a key role in the development of both sclerosis / stenosis in the aortic valve .
Prospective trials in Canada and Europe are now ongoing ( ASTRONOMER -- Aortic Stenosis Progression Observation Measuring Effects of Rosuvastatin ; SEAS -- Simvastatin and the Ezetimibe in Aortic Stenosis ) and will address the use of cholesterol - lowering drugs in reducing the progression of aortic valve stenosis and in improving clinical outcomes .
Prospective trials in Canada and Europe are now ongoing ( ASTRONOMER -- Aortic Stenosis Progression Observation Measuring Effects of Rosuvastatin ; SEAS -- Simvastatin and the Ezetimibe in Aortic Stenosis ) and will address the use of cholesterol - lowering drugs in reducing the progression of aortic valve stenosis and in improving clinical outcomes .
Prospective trials in Canada and Europe are now ongoing ( ASTRONOMER -- Aortic Stenosis Progression Observation Measuring Effects of Rosuvastatin ; SEAS -- Simvastatin and the Ezetimibe in Aortic Stenosis ) and will address the use of cholesterol - lowering drugs in reducing the progression of aortic valve stenosis and in improving clinical outcomes .
Prospective trials in Canada and Europe are now ongoing ( ASTRONOMER -- Aortic Stenosis Progression Observation Measuring Effects of Rosuvastatin ; SEAS -- Simvastatin and the Ezetimibe in Aortic Stenosis ) and will address the use of cholesterol - lowering drugs in reducing the progression of aortic valve stenosis and in improving clinical outcomes .
Prospective trials in Canada and Europe are now ongoing ( ASTRONOMER -- Aortic Stenosis Progression Observation Measuring Effects of Rosuvastatin ; SEAS -- Simvastatin and the Ezetimibe in Aortic Stenosis ) and will address the use of cholesterol - lowering drugs in reducing the progression of aortic valve stenosis and in improving clinical outcomes .
Prospective trials in Canada and Europe are now ongoing ( ASTRONOMER -- Aortic Stenosis Progression Observation Measuring Effects of Rosuvastatin ; SEAS -- Simvastatin and the Ezetimibe in Aortic Stenosis ) and will address the use of cholesterol - lowering drugs in reducing the progression of aortic valve stenosis and in improving clinical outcomes .
Cardiologists long assumed that aortic valve sclerosis / stenosis is a wear - and - tear , degenerative process ; recent studies suggested that lipoproteins can play a key role in the development of both sclerosis / stenosis in the aortic valve .
Cardiologists long assumed that aortic valve sclerosis / stenosis is a wear - and - tear , degenerative process ; recent studies suggested that lipoproteins can play a key role in the development of both sclerosis / stenosis in the aortic valve .
Experimental , clinical and epidemiological data support the link between aortic valvulopathy and atherosclerosis : both are caused by inflammation , lipid deposition , and accumulation of extracellular bone matrix protein .
Experimental , clinical and epidemiological data support the link between aortic valvulopathy and atherosclerosis : both are caused by inflammation , lipid deposition , and accumulation of extracellular bone matrix protein .
Prospective trials in Canada and Europe are now ongoing ( ASTRONOMER -- Aortic Stenosis Progression Observation Measuring Effects of Rosuvastatin ; SEAS -- Simvastatin and the Ezetimibe in Aortic Stenosis ) and will address the use of cholesterol - lowering drugs in reducing the progression of aortic valve stenosis and in improving clinical outcomes .
Prospective trials in Canada and Europe are now ongoing ( ASTRONOMER -- Aortic Stenosis Progression Observation Measuring Effects of Rosuvastatin ; SEAS -- Simvastatin and the Ezetimibe in Aortic Stenosis ) and will address the use of cholesterol - lowering drugs in reducing the progression of aortic valve stenosis and in improving clinical outcomes .
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